Garvy B A, Harmsen A G
Trudem Institute, Inc. Saranac Lake, New York 12983, USA.
Inflammation. 1996 Oct;20(5):499-512. doi: 10.1007/BF01487042.
Neonatal mice succumbed to intranasally-inoculated Streptococcus pneumoniae doses which were as much as 250 times less than the doses that adult mice were resistant to. Neutrophil migration into lungs of neonates was similar in kinetics and intensity to that in adults in response to lethal doses of S. pneumoniae. Interestingly, neutrophil infiltration into the lung alveoli of neonates occurred at lower doses of bacteria than that required for similar responses in adults. Furthermore, depletion of neutrophils in adult and neonatal mice inoculated with low doses of bacteria resulted in significantly higher lung burdens of bacteria in neonatal mice as compared to adults. These data indicate that increased susceptibility of neonates to S. pneumoniae is not the result of incompletely developed neutrophil function and infact, indicate that neutrophils contribute more to resistance to low doses of S. pneumoniae in neonates than they do in adult mice.
新生小鼠死于经鼻接种的肺炎链球菌，其剂量比成年小鼠能够耐受的剂量低多达250倍。在致死剂量的肺炎链球菌作用下，新生小鼠肺部中性粒细胞的迁移在动力学和强度上与成年小鼠相似。有趣的是，与成年小鼠类似反应所需的细菌剂量相比，较低剂量的细菌即可使新生小鼠肺泡出现中性粒细胞浸润。此外，接种低剂量细菌的成年和新生小鼠体内中性粒细胞耗竭后，与成年小鼠相比，新生小鼠肺部细菌负荷显著更高。这些数据表明，新生小鼠对肺炎链球菌易感性增加并非中性粒细胞功能发育不完全所致，实际上，这表明中性粒细胞在新生小鼠抵抗低剂量肺炎链球菌方面比在成年小鼠中发挥的作用更大。
