Miller B H, Rosado-de-Christenson M L, Mason A C, Fleming M V, White C C, Krasna M J
Department of Radiologic Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA.
Radiographics. 1996 May;16(3):613-44. doi: 10.1148/radiographics.16.3.8897628.
Malignant pleural mesothelioma (MPM) is a rare malignant neoplasm that typically affects individuals occupationally exposed to asbestos through a variety of industries. The patients experience an insidious onset of symptoms, including dyspnea, chest pain, cough, malaise, and weight loss. The pathologic diagnosis of MPM is difficult, and special stains or immunohistochemical or ultrastructural analysis may be required to differentiate MPM from metastatic adenocarcinoma. The tumor affects both the parietal and visceral pleural surfaces and progresses to encase the lung and invade the lung, mediastinum, and chest wall. Radiologically, MPM manifests as unilateral pleural effusion, pleural nodules, or pleural masses. Imaging studies are useful for diagnosis and staging in patients who are potential surgical candidates. Although a variety of multimodality therapies are available and radical surgical procedures have been developed, the prognosis remains dismal.
恶性胸膜间皮瘤（MPM）是一种罕见的恶性肿瘤，通常影响通过各种行业职业性接触石棉的个体。患者症状隐匿起病，包括呼吸困难、胸痛、咳嗽、不适和体重减轻。MPM的病理诊断困难，可能需要特殊染色、免疫组织化学或超微结构分析以将MPM与转移性腺癌区分开来。肿瘤累及壁层和脏层胸膜表面，并进展为包裹肺并侵犯肺、纵隔和胸壁。在放射学上，MPM表现为单侧胸腔积液、胸膜结节或胸膜肿块。影像学检查对潜在手术候选患者的诊断和分期有用。尽管有多种多模式治疗方法可用且已开发出根治性手术程序，但预后仍然不佳。
