Receptor inactivation by dye-neuropeptide conjugates: 1. The synthesis of Cys-containing dye-neuropeptide conjugates.
作者信息
Feigenbaum J J, Choubal M D, Payza K, Kanofsky J R, Crumrine D S
机构信息
Department of Research and Development, American Institute of Biotechnology, Elk Grove Village, IL 60007, USA.
出版信息
Peptides. 1996;17(6):991-4. doi: 10.1016/0196-9781(96)00167-2.
PMID:8899818
Abstract
In an attempt to attenuate specifically identified receptors through photolysis, a four-step synthesis is of a useful tethered derivative of Azure-B (Az) was developed After characterization, this derivative was covalently attached to CFMRFamide, CFMRF, and CLRFamide (i.e., three different neuropeptide analogues of the putative neurotransmitter FMRFamide. This resulted in the formation of three dye-neuropeptide conjugates: Az-CFMRFamide, Az-CFMRF, and Az-CLRFamide.
摘要
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