Christopher-Hennings J, Kurzman I D, Haffa A L, Kemnitz J W, Macewen E G
Department of Medical Sciences, University of Wisconsin, Madison 53706, USA.
In Vivo. 1995 Sep-Oct;9(5):415-20.
Dehydroepiandrosterone (DHEA) lowers serum cholesterol, particularly the low density lipoprotein (LDL) fraction, in rhesus monkeys on a commercial diet (12% calories from fat, 0.0083% cholesterol). We fed rhesus monkeys a diet of 30% calories from fat and 0.1% cholesterol for 12 weeks, then commercial chow for 7 weeks. Six monkeys each received DHEA or placebo, orally for 17 weeks. Food intake increased the first 6 weeks, but decreased thereafter. Monkeys had a 22% mean weight gain while on high fat diet. DHEA monkeys had higher T4 levels than placebo monkeys at weeks 8 and 16. After 12 weeks on high fat diet, all monkeys had elevated serum cholesterol concentrations, an increase in amount and percentage of intermediate density lipoprotein and LDL cholesterol, and an increase in amount, but a decrease in percentage of high density lipoprotein cholesterol. There were no significant differences in serum cholesterol or plasma lipoprotein concentrations between DHEA and placebo monkeys while on high fat diet (a trend toward lower levels was noted in the DHEA group). On commercial chow, plasma lipoprotein concentrations decreased for all monkeys, and DHEA monkeys had significantly lower total and LDL cholesterol than placebo monkeys. We conclude that a high fat diet (30% fat) masks any cholesterol-lowering effects of DHEA.
脱氢表雄酮（DHEA）可降低食用市售饮食（脂肪提供12%的热量，胆固醇含量0.0083%）的恒河猴的血清胆固醇，尤其是低密度脂蛋白（LDL）部分。我们给恒河猴喂食脂肪提供30%热量且胆固醇含量0.1%的饮食12周，然后再喂食市售食物7周。每组6只猴子分别口服DHEA或安慰剂，持续17周。最初6周食物摄入量增加，但之后减少。在高脂饮食期间，猴子的平均体重增加了22%。在第8周和第16周时，服用DHEA的猴子的T4水平高于服用安慰剂的猴子。在高脂饮食12周后，所有猴子的血清胆固醇浓度均升高，中间密度脂蛋白和LDL胆固醇的量及百分比增加，高密度脂蛋白胆固醇的量增加但百分比降低。在高脂饮食期间，服用DHEA的猴子和服用安慰剂的猴子的血清胆固醇或血浆脂蛋白浓度没有显著差异（DHEA组有水平较低的趋势）。在食用市售食物时，所有猴子的血浆脂蛋白浓度均降低，服用DHEA的猴子的总胆固醇和LDL胆固醇显著低于服用安慰剂的猴子。我们得出结论，高脂饮食（30%脂肪）掩盖了DHEA的任何降胆固醇作用。
