重新审视钙拮抗剂在心血管医学中的临床安全性及作用。

Re-examining the clinical safety and roles of calcium antagonists in cardiovascular medicine.

作者信息

Conti C R

机构信息

Division of Cardiovascular Medicine, College of Medicine, University of Florida, Gainesville, USA.

出版信息

Am J Cardiol. 1996 Nov 7;78(9A):13-8. doi: 10.1016/s0002-9149(96)00733-3.

DOI:10.1016/s0002-9149(96)00733-3

PMID:8903280

Abstract

Despite recent analyses questioning the safety of calcium antagonists, evidence and clinical practice strongly support a major role for these drugs in the management of many cardiovascular diseases such as arrhythmia, vascular spasm, hypertension, diastolic dysfunction, stable angina, and myocardial infarction. These agents are a heterogeneous class of drugs with each formulation possessing unique properties and clinical applications. This article presents a review of the available literature and discusses the recommended use of various calcium antagonists in the treatment of diseases of the heart and vascular system.

摘要

尽管最近的分析对钙拮抗剂的安全性提出了质疑，但证据和临床实践有力地支持了这些药物在许多心血管疾病（如心律失常、血管痉挛、高血压、舒张功能障碍、稳定型心绞痛和心肌梗死）的管理中发挥主要作用。这些药物是一类异质性药物，每种制剂都具有独特的特性和临床应用。本文对现有文献进行了综述，并讨论了各种钙拮抗剂在治疗心脏和血管系统疾病中的推荐用法。