Sumimoto T, Mukai M, Murakami E, Kokubu T, Lin M, Shigematsu Y, Hamada M, Hiwada K
Hypertension Center, Kinki Central Hospital, Itami, Hyogo, Japan.
J Hypertens. 1995 Dec;13(12 Pt 2):1813-7.
To investigate the effect of age on left ventricular structure and geometry in hypertensive patients, we studied the relationship between age and echocardiographic variables in patients with uncomplicated essential hypertension.
We divided 168 patients with hypertension into three groups according to age: young (<40 years), middle-aged (40-59 years) and an elderly group (> or = 60 years). They were further categorized according to relative wall thickness and the left ventricular mass index. We then evaluated the prevalence of left ventricular geometric patterns in these patients according to age.
The left ventricular end-diastolic dimension decreased with age, both in normotensive control subjects and in hypertensive patients. The magnitude of this decrease was similar for both. The relative wall thickness and left ventricular mass index were greater in the hypertensive patients than in the normotensive control subjects, and these increased with age both in the controls and the hypertensives. The differences between normotensives and hypertensives in these variables remained unchanged with age. The prevalence of a normal left ventricle (normal relative wall thickness and left ventricular mass index) in the hypertensive patients decreased with age. Conversely, the prevalence of concentric remodeling (increased relative wall thickness with normal left ventricular mass index) and concentric hypertrophy (increased relative wall thickness and left ventricular mass index) increased with age.
These results demonstrate that age significantly affects left ventricular structure both in normotensive control subjects and in hypertensive patients. Thus, the differences in left ventricular geometric patterns with age may have important implications in assessing left ventricular structure and geometric patterns in hypertensive patients.
为研究年龄对高血压患者左心室结构和几何形态的影响，我们对单纯性原发性高血压患者的年龄与超声心动图变量之间的关系进行了研究。
我们将168例高血压患者按年龄分为三组：青年组（<40岁）、中年组（40 - 59岁）和老年组（≥60岁）。根据相对室壁厚度和左心室质量指数对他们进一步分类。然后我们根据年龄评估这些患者左心室几何形态模式的患病率。
无论是血压正常的对照者还是高血压患者，左心室舒张末期内径均随年龄增长而减小。两者减小的幅度相似。高血压患者的相对室壁厚度和左心室质量指数高于血压正常的对照者，且在对照组和高血压患者中均随年龄增长而增加。这些变量在血压正常者和高血压患者之间的差异随年龄保持不变。高血压患者中左心室正常（相对室壁厚度和左心室质量指数正常）的患病率随年龄增长而降低。相反，向心性重构（相对室壁厚度增加而左心室质量指数正常）和向心性肥厚（相对室壁厚度和左心室质量指数均增加）的患病率随年龄增长而增加。
这些结果表明，年龄对血压正常的对照者和高血压患者的左心室结构均有显著影响。因此，左心室几何形态模式随年龄的差异可能对评估高血压患者的左心室结构和几何形态模式具有重要意义。
