Albert M J, Faruque S M, Faruque A S, Bettelheim K A, Neogi P K, Bhuiyan N A, Kaper J B
International Centre for Diarrhoeal Disease Research, Bangladesh. albert%
J Clin Microbiol. 1996 Mar;34(3):717-9. doi: 10.1128/jcm.34.3.717-719.1996.
The role of cytolethal distending toxin (CDT)-producing Escherichia coli, a newly described category of E. coli, in the causation of diarrhea was studied by screening E. coli isolates from 546 children < 5 years of age with diarrhea and 215 matched controls without diarrhea by using a specific DNA probe. Although CDT-positive E. coli strains were isolated from more children with diarrhea than from healthy controls (3.1 versus 0.93%), this difference did not reach statistical significance (P = 0.082). All CDT-positive strains also possessed the virulence factors of enteropathogenic E. coli or enteroaggregative E. coli isolates.
通过使用特异性DNA探针筛查546名5岁以下腹泻儿童和215名匹配的无腹泻对照儿童的大肠杆菌分离株，研究了产细胞致死膨胀毒素（CDT）的大肠杆菌（一种新描述的大肠杆菌类别）在腹泻病因中的作用。虽然从腹泻儿童中分离出的CDT阳性大肠杆菌菌株比健康对照儿童多（3.1%对0.93%），但这种差异未达到统计学显著性（P = 0.082）。所有CDT阳性菌株还具有肠致病性大肠杆菌或肠聚集性大肠杆菌分离株的毒力因子。
