麦角酸二乙酰胺（LSD）与三甲氧苯乙胺（mescaline）结构关系的新观点。

A new view of the structural relationship between LSD and mescaline.

作者信息

Nichols D E, Pfister W R, Yim G K, Cosgrove R J

出版信息

Brain Res Bull. 1977 May-Jun;2(3):169-71. doi: 10.1016/0361-9230(77)90034-x.

Abstract

An examination of the effects of S-(-) and R-(+) 2-amino-1,2,3,4-tetrahydronaphthalene (2-AT) on mouse spontaneous activity and rabbit EEG has shown that the S-(-) enantiomer shows selective central effects similar to those of hallucinogens like mescaline. A stereochemical analysis of these results indicates that the structural relationship between mescaline, or other phenethylamine type hallucinogens, may involve correspondence between the aromatic ring of the phenethylamines and the pyrrole portion of the indole nucleus in LSD.

摘要

对S-(-)和R-(+) 2-氨基-1,2,3,4-四氢萘（2-AT）对小鼠自发活动及家兔脑电图影响的研究表明，S-(-)对映体显示出类似于三甲氧苯乙胺等致幻剂的选择性中枢效应。对这些结果的立体化学分析表明，三甲氧苯乙胺或其他苯乙胺类致幻剂之间的结构关系，可能涉及苯乙胺的芳香环与麦角酸二乙胺中吲哚核的吡咯部分之间的对应关系。