Masserano J M, Baker I, Natsukari N, Wyatt R J
National Institute of Mental Health, Neuropsychiatry Branch Neuroscience Center at Saint Elizabeths, Washington, DC, USA.
Neurosci Lett. 1996 Oct 18;217(2-3):73-6.
Tyrosine hydroxylase activity was measured in the brain of rats treated chronically with saline or cocaine (10 mg/kg, 2 x day, for 7 days). Tyrosine hydroxylase activity was significantly increased in the ventral tegmental area 1, 6 and 12 weeks after the last treatment with cocaine. The increase in tyrosine hydroxylase activity at 6 weeks after the last cocaine injection was prevented by the prior administration of MK-801, haloperidol or clozapine but not by the D1 receptor antagonist, SCH-23390. SCH-23390 produced a significant increase in tyrosine hydroxylase activity when administered with saline. These data indicate that glutaminergic and dopaminergic D2-receptor mediated mechanisms are important in regulating the effect of cocaine on the ventral tegmental area.
用生理盐水或可卡因（10毫克/千克，每天2次，共7天）对大鼠进行长期处理后，检测其大脑中的酪氨酸羟化酶活性。在最后一次给予可卡因后1、6和12周，腹侧被盖区的酪氨酸羟化酶活性显著增加。在最后一次注射可卡因6周后，预先给予MK-801、氟哌啶醇或氯氮平可阻止酪氨酸羟化酶活性的增加，但D1受体拮抗剂SCH-23390则不能。当与生理盐水一起给药时，SCH-23390可使酪氨酸羟化酶活性显著增加。这些数据表明，谷氨酸能和多巴胺能D2受体介导的机制在调节可卡因对腹侧被盖区的作用中很重要。
