苯丙胺对分离和聚集大鼠脑内生物胺的影响。

Effects of amphetamine on brain biogenic amines in isolated and aggregated rats.

作者信息

Lokiec F, Jacquot C, Rapin J R, Cohen Y

出版信息

Eur J Pharmacol. 1977 Aug 15;44(4):391-5. doi: 10.1016/0014-2999(77)90314-4.

Abstract

d- and 1-amphetamine were injected (15 mg/kg i.p.) into isolated or aggregated rats. Both d- and 1-forms decreased the noradrenaline levels of brain areas in isolated and in aggregated rats. d-Amphetamine decreased 5-hydroxytryptamine (5-HT) and 5-hydroxyindolacetic acid (5-hiaa) levels in aggregated rats only. 1-Amphetamine induced no change in 5-HT and 5-HIAA levels. The greater sensitivity of aggregated rats to d-amphetamine can be ascribed to a change in 5-HT metabolism rather than to a modification of noradrenaline levels.

摘要

将右旋和左旋苯丙胺（腹腔注射，剂量为15毫克/千克）注射到单独饲养或群居的大鼠体内。右旋和左旋两种形式都降低了单独饲养和群居大鼠脑区的去甲肾上腺素水平。右旋苯丙胺仅降低了群居大鼠体内的5-羟色胺（5-HT）和5-羟吲哚乙酸（5-HIAA）水平。左旋苯丙胺对5-HT和5-HIAA水平没有影响。群居大鼠对右旋苯丙胺的更高敏感性可归因于5-HT代谢的变化，而非去甲肾上腺素水平的改变。