组胺H1和H2受体激动剂对犬猫的血管作用

Vascular actions of histamine H1- and H2-receptor agonists in dogs and cats.

作者信息

Tucker A, Hoffman E A, Reeves J T

出版信息

Eur J Pharmacol. 1977 Sep 1;45(1):73-7. doi: 10.1016/0014-2999(77)90060-7.

Abstract

Systemic and pulmonary vascular responses to infusions of histamine, 2-methylhistamine (2-MeH), and 4-methylhistamine (4-MeH) were determined. In dogs, H1-receptor stimulation with 2-MeH induced pulmonary vasoconstriction, and a decrease in cardiac output. H2-receptor stimulation with 4-MeH induced pulmonary and systemic vasodilation, tachycardia, and an increase in cardiac output. In cats, 2-MeH caused slight pulmonary vasoconstriction and 4-MeH caused vasodilation. Both H1- and H2-receptors mediated the systemic vasodilation, tachycardia, and increase in cardiac output observed in cats.

摘要

测定了组胺、2-甲基组胺（2-MeH）和4-甲基组胺（4-MeH）输注后的全身和肺血管反应。在犬中，用2-MeH刺激H1受体可引起肺血管收缩和心输出量降低。用4-MeH刺激H2受体可引起肺血管和全身血管舒张、心动过速和心输出量增加。在猫中，2-MeH引起轻微的肺血管收缩，4-MeH引起血管舒张。H1和H2受体均介导了猫中观察到的全身血管舒张、心动过速和心输出量增加。