乙基-6-O-癸酰葡萄糖苷与氯己定在隐形眼镜消毒中的协同作用。

Synergistic effect of ethyl-6-O-decanoyl glucoside and chlorhexidine in contact lens disinfection.

作者信息

Lehtonen O J, Vaahtoranta-Lehtonen H, Leivo P, Mäki M

机构信息

Turku University Central Hospital, Finland.

出版信息

APMIS. 1996 Jul-Aug;104(7-8):603-6. doi: 10.1111/j.1699-0463.1996.tb04918.x.

DOI:10.1111/j.1699-0463.1996.tb04918.x

PMID:8920816

Abstract

Contact lenses with adherent Serratia marcescens and Pseudomonas aeruginosa could not be sterilised either with polyaminopropyl biguanide or with chlorhexidine (CHX) commercial solutions meant for contact lens disinfection, even after treatment lasting 12 h. Ethyl-6-O-decanoyl glucoside (EDG) with chlorhexidine enhanced the killing significantly. The same was also found to be the case for dispersed cells of P. aeruginosa on cellulose acetate filters. EDG enhances the bactericidal effect of 0.00025 CHX by a mechanism not solely due to detergent action and is a potential adjunct to CHX in clinical applications.

摘要

带有黏附的粘质沙雷氏菌和铜绿假单胞菌的隐形眼镜，即使经过长达12小时的处理，使用用于隐形眼镜消毒的聚氨基丙基双胍或氯己定（CHX）商业溶液也无法灭菌。己基-6-O-癸酰葡萄糖苷（EDG）与氯己定联用可显著增强杀菌效果。对于醋酸纤维素滤膜上分散的铜绿假单胞菌细胞，情况也是如此。EDG增强了0.00025 CHX的杀菌作用，其机制并非仅仅归因于去污剂作用，在临床应用中它是CHX的潜在辅助剂。