Forgács E, Demnerová K
Central Research Institute for Chemistry, Hungarian Academy of Sciences, Budapest, Hungary.
Biomed Chromatogr. 1996 Mar-Apr;10(2):92-4. doi: 10.1002/(SICI)1099-0801(199603)10:2<92::AID-BMC562>3.0.CO;2-3.
The binding of polychlorinated biphenyls (PCBs) to hydroxypropyl-beta-cyclodextrin (HP-beta-CD), tau-cyclodextrin (tau-CD) and sodium dodecylsulphate (SDS) was studied by reversed-phase thin-layer chromatography and the relative strength of interaction was calculated. HP-beta-CD and SDS did not bind to PCBs making it unlikely that these compounds modify the adsorption capacity or decomposition rate of PCBs. Each PCB formed inclusion complexes with tau-cyclodextrin. The inclusion-forming capacity of PCBs increased with an increase in the number of chloro substitutions in the molecule, indicating that tau-CD can be successfully used for the modification of the physicochemical and biochemical characteristics of PCBs. The linear correlation between the hydrophobicity and specific hydrophobic area of PCBs indicated that they can be considered as a homologous series of compounds.
通过反相薄层色谱法研究了多氯联苯（PCBs）与羟丙基-β-环糊精（HP-β-CD）、tau-环糊精（tau-CD）和十二烷基硫酸钠（SDS）的结合情况，并计算了相互作用的相对强度。HP-β-CD和SDS不与PCBs结合，这使得这些化合物不太可能改变PCBs的吸附能力或分解速率。每种PCBs都与tau-环糊精形成了包合物。PCBs的包合形成能力随着分子中氯取代基数目的增加而增强，这表明tau-CD可成功用于改变PCBs的物理化学和生化特性。PCBs的疏水性与比疏水面积之间的线性相关性表明，它们可被视为一系列同系物。
