21-氨基类固醇U74006F对急性实验性变应性脑脊髓炎临床病程的影响。
The effect of the 21-aminosteroid U74006F on the clinical course of acute experimental allergic encephalomyelitis.
作者信息
Uitdehaag B M, Polman C H, Sontrop K, Dijkstra C D
机构信息
Department of Neurology, Free University Hospital, Amsterdam, Netherlands.
出版信息
J Neurol Sci. 1996 Jan;135(1):18-20. doi: 10.1016/0022-510x(95)00262-z.
We evaluated the clinical effect of several doses of the 21-aminosteroid U74006F in acute experimental autoimmune encephalomyelitis (EAE) and compared it with the administration of methylprednisolone (MP). There was no significant change in the clinical course of EAE with the dosages we used, whereas the effect of MP was unquestionably beneficial. Based on these results U74006F does not seem to be a promising drug for the treatment of exacerbations of multiple sclerosis.
我们评估了几种剂量的21-氨基类固醇U74006F在急性实验性自身免疫性脑脊髓炎（EAE）中的临床效果，并将其与甲基强的松龙（MP）的给药效果进行了比较。我们所使用的剂量对EAE的临床病程没有显著影响，而MP的效果无疑是有益的。基于这些结果，U74006F似乎不是治疗多发性硬化症病情加重的理想药物。
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