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莫比来登对人体饮酒效果的影响。首次报道:对乙醇药代动力学的影响。

Influence of Mobiletten on the effect of alcohol drinking in man. First communication: Influence on the pharmacokinetics of ethanol.

作者信息

Kraemer R, Mallach H J, Raff G, Schulz H

出版信息

Int J Clin Pharmacol Biopharm. 1977 Jul;15(7):301-9.

PMID:892946
Abstract

The interaction of the drug Mobiletten with the pharmacokinetics of ethanol was studied in 15 probands. In these experiments, the maximal ethanol concentrations in blood were found to be significantly decreased and delayed. The ethanol elimination remained unchanged. The uptake of Mobiletten resulted in a remarkable decrease of the urine volume. The quantitative determination of the ethanol content in the expired air by alcotest technique was not significantly affected.

摘要

在15名受试者中研究了药物莫比来汀与乙醇药代动力学的相互作用。在这些实验中,发现血液中乙醇的最大浓度显著降低且出现延迟。乙醇消除情况保持不变。服用莫比来汀导致尿量显著减少。通过酒精测试技术对呼出气体中乙醇含量进行的定量测定未受到显著影响。

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