5-氟尿嘧啶和亚叶酸钙用于复发性原发性脑肿瘤的II期研究。
Phase II study of 5-fluorouracil and leucovorin in recurrent primary brain tumor.
作者信息
Cascino T L, Veeder M H, Buckner J C, O'Fallon J R, Wiesenfeld M, Levitt R, Goldberg R M, Kuross S A, Morton R F, Scheithauer B W
机构信息
Mayo Clinic, Rochester, MN 55905, USA.
出版信息
J Neurooncol. 1996 Dec;30(3):243-6. doi: 10.1007/BF00177275.
PMID:8943099
Abstract
Thirty patients with recurrent primary brain tumors were treated with a combination of 5-fluorouracil and leucovorin. There were three responses seen. Toxicity consisted of stomatitis, diarrhea, and hematological suppression. 5-fluorouracil and leucovorin would appear to be minimally effective in recurrent brain tumors.
摘要
30例复发性原发性脑肿瘤患者接受了5-氟尿嘧啶和亚叶酸联合治疗。观察到3例有反应。毒性包括口腔炎、腹泻和血液学抑制。5-氟尿嘧啶和亚叶酸对复发性脑肿瘤似乎疗效甚微。
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