Transcription factors as drug targets in cancer.

Within multicellular organisms, cells are continually signalling to each other to keep in tune with their environment. The ultimate targets for the majority of these signal pathways are upstream transcription factors, whose activity is thereby modulated, resulting in a new pattern of gene expression suitably coupled to the needs of the cell. It has been estimated that up to 10% of human genes may encode transcription factors, thus emphasising how fundamental the control of gene expression is to the processes of cellular division and differentiation during normal development. As a corollary of this, transcriptional regulation can also profoundly affect the course of growth-related diseases such as cancer. Of course it has been realised for some time that the normal counterparts of many oncogenes are transcription factors whose proper role is in the control of normal cell growth. More recent work has begun to identify several other transcription factors which may play a role in cancer, and strategies are now being developed which are designed to use our growing knowledge of transcriptional control mechanisms in the development of novel cancer therapies.