[硝碘酚腈衍生物的血浆和肝脏水解研究]
[Study of plasma and hepatic hydrolysis of nitroxinil derivatives].
作者信息
Baziard-Mouysset G, Alvinerie M, Galtier P, Ane-Margail M, Floch R, Payard M
机构信息
Laboratoire de Chimie Pharmaceutique, Faculté de Pharmacie, Toulouse.
出版信息
Ann Pharm Fr. 1996;54(5):223-7.
PMID:8953797
Abstract
Seven esters derivatives of Nitroxinil were prepared and their structures were assigned by IR and 1H-NMR spectroscopy. The rate of plasma and hepatic hydrolysis were evaluated in vitro in sheep and rabbit. In view of this profile of activity, pivaloyl derivative merits evaluation, in vivo.
摘要
制备了硝碘酚腈的七种酯衍生物，并通过红外光谱和1H-NMR光谱确定了它们的结构。在绵羊和兔子体内对其血浆和肝脏水解速率进行了体外评估。鉴于这种活性特征，新戊酰衍生物值得进行体内评估。
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