Carroll J, Dluhy R, Fallo F, Pistorello M, Bradwin G, Gomez-Sanchez C E, Mortensen R
Endocrine Division, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
J Clin Endocrinol Metab. 1996 Dec;81(12):4310-2. doi: 10.1210/jcem.81.12.8954032.
In glucocorticoid-remediable aldosteronism (GRA) a chimeric gene has been described with the activity of aldosterone synthase, but the promoter of 11 beta-hydroxylase leading to ectopic expression of aldosterone synthase activity in the zona fasciculata. Similar to GRA, in aldosterone-producing adenomas (APA), the primary regulation of aldosterone production is ACTH, and there is increased production of the 18-oxygenated cortisol compounds, 18-oxocortisol and 18-hydroxycortisol. Because of these hormonal similarities, we tested whether a chimeric GRA-like gene was present in APA from 11 patients. A GRA-like chimeric gene was not found in the DNA from these tumors and, therefore, is not the mechanism responsible for hyperaldosteronism in APA.
在糖皮质激素可治性醛固酮增多症（GRA）中，已描述了一种嵌合基因，其具有醛固酮合酶的活性，但有11β-羟化酶的启动子，导致醛固酮合酶活性在束状带异位表达。与GRA相似，在醛固酮瘤（APA）中，醛固酮产生的主要调节因子是促肾上腺皮质激素（ACTH），并且18-氧代皮质醇化合物、18-氧代皮质醇和18-羟皮质醇的产生增加。由于这些激素方面的相似性，我们检测了11例患者的APA中是否存在类似GRA的嵌合基因。在这些肿瘤的DNA中未发现类似GRA的嵌合基因，因此，它不是APA中醛固酮增多症的发病机制。
