低出生体重新生儿的卡介苗接种：淋巴细胞增殖、白细胞介素-2生成及对结核菌素纯蛋白衍生物的皮内反应分析

BCG vaccination in low birth weight newborns: analysis of lymphocyte proliferation, IL-2 generation and intradermal reaction to PPD.

作者信息

Ferreira A A, Bunn-Moreno M M, Sant'Anna C C, Ferreira M F

机构信息

Department of Pediatrics, School of Medicine, Federal University of Mato Grosso, MT, Brazil.

出版信息

Tuber Lung Dis. 1996 Oct;77(5):476-81. doi: 10.1016/s0962-8479(96)90123-9.

DOI:10.1016/s0962-8479(96)90123-9

PMID:8959154

Abstract

OBJECTIVE

To study vaccinal scar formation and post-vaccinal immune response in newborns with birth weight ranging from 2000 to 2499 g vaccinated in the first week of life with intradermal bacille Calmette-Guérin (BCG) (Moreau-Rio de Janeiro strain).

METHOD

Specific immune response to PPD was assessed in 30 low birth weight newborns (mean birth weight = 2311.7 +/- 122.1 g; mean gestational age = 38.1 +/- 1.8 weeks) in comparison to 56 control infants (mean birth weight = 3198.9 +/- 267.2 g; mean gestational age = 38.5 +/- 1.2 weeks.

RESULTS

Low birth weight infants have an efficient immune response to vaccinal stimulus when compared to control infants as judged by specific in vitro lymphocyte proliferation (mean SI = 9.7 +/- 12.9 vs SI = 8.8 +/- 10.0, P = 0.72) and IL-2 production (mean SI = 3.1 +/- 3.4 vs SI = 2.6 +/- 2.0, P = 0.38). Intradermal reaction to PPD was also comparable in both groups (mean induration diameter = 9.5 +/- 5.1 mm vs 9.6 +/- 5.0 mm, P = 0.94).

CONCLUSION

These data suggest that low birth weight newborns show a good immune response to BCG, thus reinforcing the inclusion of such infants in regular vaccination programs with intradermal BCG.

摘要

目的

研究出生体重在2000至2499克之间、于出生后第一周接种皮内卡介苗（卡介苗，莫罗-里约热内卢株）的新生儿的疫苗接种疤痕形成情况及接种后免疫反应。

方法

评估了30名低出生体重新生儿（平均出生体重 = 2311.7 +/- 122.1克；平均胎龄 = 38.1 +/- 1.8周）对PPD的特异性免疫反应，并与56名对照婴儿（平均出生体重 = 3198.9 +/- 267.2克；平均胎龄 = 38.5 +/- 1.2周）进行比较。

结果

通过特异性体外淋巴细胞增殖（平均刺激指数 = 9.7 +/- 12.9对刺激指数 = 8.8 +/- 10.0，P = 0.72）和IL-2产生情况（平均刺激指数 = 3.1 +/- 3.4对刺激指数 = 2.6 +/- 2.0，P = 0.38）判断，与对照婴儿相比，低出生体重婴儿对疫苗刺激具有有效的免疫反应。两组对PPD的皮内反应也相当（平均硬结直径 = 9.5 +/- 5.1毫米对9.6 +/- 5.0毫米，P = 0.94）。