de Groot M H, Nolen W A, Huijsman A M, Bouvy P F
Psychiatric Center Bloemendaal, The Hague, The Netherlands.
Biol Psychiatry. 1996 Dec 15;40(12):1282-7. doi: 10.1016/0006-3223(95)00654-0.
Several decades of research have led to different hypotheses about cognitive functioning in depression; one of the hypotheses states that there is altered functioning of the hemispheres during a depressive episode. Lateralization studies have found diminished neuropsychological functioning in depressive patients; especially right-hemisphere functions seem impaired. In our study we used conventional neuropsychological tests to study shifts in hemispheric functioning. Neuropsychological testing before and after therapy in 52 (for the most part therapy-resistant) depressives showed no substantial effects in lateralized functioning. None of the measures enabled prediction of response to treatment; however 17 different interaction variables were identified, five of which make an unique contribution.
几十年的研究产生了关于抑郁症认知功能的不同假说；其中一个假说认为，在抑郁发作期间半球功能会发生改变。偏侧化研究发现抑郁症患者的神经心理功能有所减退；尤其是右半球功能似乎受损。在我们的研究中，我们使用传统的神经心理测试来研究半球功能的变化。对52名（大部分对治疗有抵抗性的）抑郁症患者在治疗前后进行神经心理测试，结果显示在偏侧化功能方面没有实质性影响。没有一项测量能够预测治疗反应；然而，确定了17个不同的交互变量，其中5个变量有独特的作用。
