Naylor G P, Harrison J D
National Radiological Protection Board, Oxon, UK.
Hum Exp Toxicol. 1995 Dec;14(12):949-54. doi: 10.1177/096032719501401203.
The gastrointestinal absorption of Fe and Co by rats and guinea pigs of different ages was measured by comparing the whole-body retention of 59Fe and 57Co after oral and intraperitoneal administrations. The age-groups studied included newborn, weanlings and adults. The absorption of both Fe and Co decreased markedly with age in both rats and guinea pigs. In the rat, absorption remained elevated during the suckling period, while in the guinea pig absorption decreased markedly during suckling. In both species, Fe and Co absorption were similar, and remained elevated above adult values for some time after weaning. The generally greater absorption of Fe and Co by rats than by guinea pigs and the longer duration of maximal absorption in the rats may have involved differences in Fe status in the two species and differences in the timing of gut maturation.
通过比较口服和腹腔注射后大鼠和豚鼠对⁵⁹Fe和⁵⁷Co的全身潴留情况，测定了不同年龄大鼠和豚鼠对铁（Fe）和钴（Co）的胃肠道吸收。研究的年龄组包括新生动物、断奶幼崽和成年动物。大鼠和豚鼠体内铁和钴的吸收均随年龄显著下降。在大鼠中，哺乳期铁的吸收仍保持较高水平，而豚鼠在哺乳期铁的吸收则显著下降。在这两个物种中，铁和钴的吸收情况相似，断奶后一段时间内仍高于成年动物的水平。大鼠对铁和钴的吸收通常比豚鼠更高，且大鼠最大吸收持续时间更长，这可能与两个物种的铁状态差异以及肠道成熟时间差异有关。
