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[酒精性肝病患者中无结肠病变证据的牛链球菌所致菌血症和心内膜炎]

[Bacteremia and endocarditis caused by Streptococcus bovis in patients with alcoholic hepatopathy without evidence of colonic pathology].

作者信息

Castroagudín J F, Lorenzo Solar M, Martínez Rey C, Brage Varela A, Torre J A, González Quintela A

机构信息

Complejo Hospitalario Universitario, Santiago de Compostela, Servicio de Aparato Digestivo.

出版信息

Rev Esp Enferm Dig. 1996 Sep;88(9):605-8.

PMID:8962774
Abstract

The association of Streptococcus bovis bacteremia and endocarditis with colonic pathology, mainly neoplastic, is well known. Its relationship with liver disease without evidence of gastrointestinal disease has been rarely described. To analyze the association between S. bovis infection and liver disease, positive blood cultures for this microorganism in hospitalized patients in the Internal Medicine and Gastroenterology Departments from December 1993 until October 1995, have been reviewed. Three cases of S. bovis infection (one bacteremia, two endocarditis) were found. Alcoholic liver disease was diagnosed in all three patients, with associated hepatitis C virus in one of them. Colonic pathology was excluded by colonoscopy and/or barium enema. Other gastrointestinal disorders were excluded by means of gastroscopy, barium gastrointestinal study and abdominal ultrasonography. Antibiotic therapy was based in betalactamics, with associated aminoglycoside in two cases. One patient needed aortic and mitral valve replacement and another one needed orthotopic liver transplantation. No new gastrointestinal pathology emerged in the follow-up (5-23 months). Cases of S. bovis bacteremia and endocarditis should be screened not also for colonic pathology, but also for liver disease, particularly in alcoholics.

摘要

牛链球菌菌血症和心内膜炎与结肠病变(主要是肿瘤性病变)的关联已广为人知。其与无胃肠道疾病证据的肝脏疾病之间的关系鲜有描述。为分析牛链球菌感染与肝脏疾病之间的关联,我们回顾了1993年12月至1995年10月在内科和胃肠病科住院患者中该微生物血培养阳性的情况。发现了3例牛链球菌感染病例(1例菌血症,2例心内膜炎)。所有3例患者均被诊断为酒精性肝病,其中1例伴有丙型肝炎病毒感染。通过结肠镜检查和/或钡剂灌肠排除了结肠病变。通过胃镜检查、胃肠道钡剂造影和腹部超声检查排除了其他胃肠道疾病。抗生素治疗以β-内酰胺类为主,2例联合使用氨基糖苷类。1例患者需要进行主动脉和二尖瓣置换,另1例需要进行原位肝移植。随访(5 - 23个月)期间未出现新的胃肠道病变。对于牛链球菌菌血症和心内膜炎病例,不仅应筛查结肠病变,还应筛查肝脏疾病,尤其是在酗酒者中。

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