Wattel F, Mathieu D, Nevière R
Service d'Urgence Respiratoire, de Réanimation Médicale et de Médecine Hyperbare, Hôpital Calmette, CHRU de Lille, France.
Bull Acad Natl Med. 1996 May;180(5):949-63; discussion 963-4.
Pathophysiologic mechanisms involved in the application of HBO therapy are poorly understood that may limit its clinical use. However, useful indications are well standardized in the setting of critical care medicine, CO poisoning, decompression sickness, gas gangrene and soft tissue anaerobic infections, crush syndrome, burns, sudden deafness... HBO therapy is also indicated in the management of chronic limb ischemia, diabetic foot lesion, osteomyelitis, osteoradionecrosis. These clinical indications have been evaluated in a Consensus Conference on Hyperbaric Medicine that has classified its application according to its efficiency. Indications were classified as strongly recommended (positively affects the patient's survival), recommended (does not influence the patient's survival but is important for the prevention of serious disorders) and optional (regarded as a additional treatment modality). Clinical application of HBO therapy requires specific equipment including a multiplace hyperbaric chamber and specific educational program and training for personnel employed in the clinical hyperbaric center. Lastly, HBO therapy is related to accurate rules defining its indications as well as its evaluation that are minimal prerequisites for safety and clinical results.
高压氧(HBO)治疗所涉及的病理生理机制尚未完全明确,这可能限制了其临床应用。然而,在重症医学、一氧化碳中毒、减压病、气性坏疽和软组织厌氧菌感染、挤压综合征、烧伤、突发性耳聋等方面,其有效适应症已有明确规范。HBO治疗也适用于慢性肢体缺血、糖尿病足病变、骨髓炎、放射性骨坏死的治疗。这些临床适应症在一次高压氧医学共识会议上进行了评估,并根据其疗效对其应用进行了分类。适应症分为强烈推荐(对患者生存有积极影响)、推荐(不影响患者生存但对预防严重疾病很重要)和可选(视为一种额外的治疗方式)。HBO治疗的临床应用需要特定的设备,包括多人高压氧舱,以及针对临床高压氧中心工作人员的特定教育计划和培训。最后,HBO治疗与明确其适应症及评估的准确规则相关,这些是安全和临床效果的最低前提条件。