Doria M I, Saint Martin G, Wang H H, Blumstein A, Jensen J A, Maslan A M, Gattuso P
Department of Cytology, Loyola University Medical Center, Chicago, IL, USA.
Diagn Cytopathol. 1996 Mar;14(2):150-4. doi: 10.1002/(SICI)1097-0339(199603)14:2<150::AID-DC9>3.0.CO;2-N.
Clear cell carcinoma (CCL) arising in the lower urinary tract is unusual and we report the cytohistologic findings of three cases retrieved from our files. All patients presented with bleeding, and the tumors were localized in either the urethra or bladder base. Filter and cytocentrifuge preparations of the urine were studied and all cases displayed numerous scattered aggregates or single tumor cells in an inflammatory background. The enlarged cells had abundant clear, wispy cytoplasm with discrete vacuolation. Hobnail and signet ring cells were apparent. The nuclei had granular to vesicular chromatin with prominent often multiple nucleoli. The tumors were histologically distinctive and typically had a tubulocystic configuration with varying proportions of papillary and diffuse patterns. One patient has died of metastatic cancer and two are presently free of tumor. The cytohistologic features of this cancer are characteristic and from our review we conclude that this lesion can be diagnosed by cytologic means.
下尿路发生的透明细胞癌（CCL）较为罕见，我们报告从我们档案中检索出的3例病例的细胞组织学发现。所有患者均有出血症状，肿瘤位于尿道或膀胱底部。对尿液的滤过和细胞离心涂片进行了研究，所有病例在炎性背景中均显示有大量散在的聚集物或单个肿瘤细胞。细胞增大，有丰富的透明、纤细的胞质，伴有离散的空泡形成。鞋钉样细胞和印戒样细胞明显。细胞核有颗粒状至泡状染色质，常有多个明显的核仁。肿瘤在组织学上具有独特性，通常呈管状囊性结构，伴有不同比例的乳头状和弥漫性模式。1例患者死于转移性癌症，2例目前无肿瘤。这种癌症的细胞组织学特征具有特异性，通过我们的回顾，我们得出结论，这种病变可以通过细胞学方法诊断。
