戊二酰卵磷脂对人红细胞的作用（作者译）

[Effect of glutaryl-lecithins on human erythrocytes (author's transl)].

作者信息

Dousset N, Quan D Q, Douste-Blazy L

出版信息

Nouv Rev Fr Hematol Blood Cells. 1977;18(1):53-61.

Abstract

Effect of glutaryl-lecithins on red blood cells is studied and compared to effect to egg lysolecithins. 1. Glutaryl-lecithins exhibit a hemolytic activity which appears in the first minutes. The rate of hemolysis increases proportionally with glutaryllecithin concentration up to concentrations of 1 X 10(-7) mole. 2. Glutaryl-lecithins methylation causes a decrease of lytic activity; this might indicate that the carboxylic group plays a role in the process of hemolysis. 3. Glutaryl-lecithins can produce echinocytes, in a similar fashion to lysolecithins. These findings suggest that glutaryl-lecithin hemolytic activity plays an important role in the process of post irradiation hemolysis.

摘要

研究了戊二酰卵磷脂对红细胞的作用，并与蛋黄溶血卵磷脂的作用进行了比较。1. 戊二酰卵磷脂表现出溶血活性，在最初几分钟内就会出现。溶血速率随戊二酰卵磷脂浓度的增加而成比例增加，直至浓度达到1×10（-7）摩尔。2. 戊二酰卵磷脂甲基化导致裂解活性降低；这可能表明羧基在溶血过程中起作用。3. 戊二酰卵磷脂可以产生棘形红细胞，其方式与溶血卵磷脂类似。这些发现表明，戊二酰卵磷脂的溶血活性在辐射后溶血过程中起重要作用。