Schaffner A
Medizinische Klinik B. Universitätsspital Zürich.
Praxis (Bern 1994). 1996 Oct 1;85(40):1236-9.
Fungal infections are of minor importance in general practice. With the possible exception of cryptococcosis in HIV-infected patients deep fungal infections are rarely seen in ambulatory medicine. Some exceptions are discussed. Candida spp. are normally found on the surfaces of the gastrointestinal and genital tract. The documentation of yeast from these sites is therefore not an indication for antifungal therapy. Esophagitis oral or vaginal thrush should however be treated promptly with oral fluconazole. Cutaneous mycoses are best treated topically or if too extensive with itraconazole or terbinafine. Treatment of nail infection, if treatment is warranted at all is best treated with terbinafine. Any attempts to attribute uncharacteristic complaints to an intestinal colonization with yeasts or nutritional fungal toxins lacks a scientific background. The practice to diagnose from blood films obscure fungal infections is quackery at best.
真菌感染在普通医疗实践中不太重要。除了HIV感染患者可能出现的隐球菌病外,深部真菌感染在门诊医学中很少见。文中讨论了一些例外情况。念珠菌属通常存在于胃肠道和生殖道表面。因此,从这些部位检出酵母菌并不意味着需要进行抗真菌治疗。然而,食管炎、口腔或阴道念珠菌病应立即用口服氟康唑治疗。皮肤真菌病最好局部治疗,若范围太广则用伊曲康唑或特比萘芬治疗。甲癣的治疗(如果确实需要治疗的话)最好用特比萘芬。任何将不典型症状归因于酵母菌肠道定植或营养性真菌毒素的尝试都缺乏科学依据。通过血涂片诊断隐匿性真菌感染的做法充其量只是江湖医术。