Karpinia K A, Matt M, Fennell R S, Hefti A F
Department of Periodontology, University of Florida, Gainesville, USA.
Pediatr Dent. 1996 Nov-Dec;18(7):450-5.
The purpose of this research was to study the occurrence of gingival overgrowth (GO) in children after kidney transplantation and to investigate the relationship of GO to medical and dental parameters. Forty-nine kidney transplant patients taking the immunosuppressive drug cyclosporine A (CsA) were evaluated for plaque (PI), calculus (CI), gingival inflammation (GI), probing depth (PD), width of keratinized gingiva (GW), and gingival overgrowth (GO). Blood trough levels and oral dosages of CsA were obtained from medical charts on the day of examination. Most (77.5%) subjects exhibited GO, suggesting that GO is a frequent problem in children and adolescents ingesting CsA. GI, PD, and GW were found to be statistically significantly greater in subjects with GO than in those without GO. CsA dose/day was not significantly different between subjects with GO and those without GO. CsA dose/kg body weight and blood trough levels of CsA were significantly higher in subjects without GO, but the average length of time subjects without GO had been ingesting CsA was only 1.3 months, compared with an average 3.5 years for subjects with GO. The results indicate that in young subjects, duration of CsA ingestion may be the most critical factor related to eventual GO development.
本研究的目的是研究肾移植术后儿童牙龈增生（GO）的发生情况，并探讨GO与医学及牙科参数之间的关系。对49名服用免疫抑制药物环孢素A（CsA）的肾移植患者进行了菌斑（PI）、牙石（CI）、牙龈炎症（GI）、探诊深度（PD）、角化龈宽度（GW）和牙龈增生（GO）的评估。在检查当天从病历中获取CsA的血药谷浓度和口服剂量。大多数（77.5%）受试者出现牙龈增生，这表明牙龈增生是摄入CsA的儿童和青少年中常见的问题。发现有牙龈增生的受试者的GI、PD和GW在统计学上显著高于无牙龈增生的受试者。有牙龈增生和无牙龈增生的受试者之间每日CsA剂量无显著差异。无牙龈增生的受试者的CsA剂量/体重和血药谷浓度显著更高，但无牙龈增生的受试者摄入CsA的平均时间仅为1.3个月，而有牙龈增生的受试者平均为3.5年。结果表明，在年轻受试者中，摄入CsA的持续时间可能是最终发生牙龈增生的最关键因素。
