超临界CHF3和CO2从各种食品基质中提取磺胺类药物的比较。

Comparison of supercritical CHF3 and CO2 for extraction of sulfonamides from various food matrices.

作者信息

Combs M T, Ashraf-Khorassani M, Taylor L T

机构信息

Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg 24061, USA.

出版信息

Anal Chem. 1996 Dec 15;68(24):4507-11. doi: 10.1021/ac960643q.

DOI:10.1021/ac960643q

PMID:8972629

Abstract

Supercritical CHF3 and methanol-modified CHF3 were compared with supercritical CO2 and methanol-modified CO2 for the extraction of sulfonamides from a spiked sand sample. In addition, a fortified nonfat milk powder, fortified egg yolk, and fortified beef liver were studied. The results showed CHF3 has higher solvating power and selectivity for extraction of two of the three sulfonamides than CO2. Extraction efficiencies of sulfamethazine and sulfadimethoxine using pure CHF3 were more than 45% higher from spiked sand samples and over 200% higher from fortified beef liver samples than pure CO2.

摘要

将超临界CHF₃和甲醇改性的CHF₃与超临界CO₂和甲醇改性的CO₂进行比较，用于从加标的砂样中萃取磺胺类药物。此外，还研究了强化脱脂奶粉、强化蛋黄和强化牛肝。结果表明，对于三种磺胺类药物中的两种，CHF₃在萃取时具有比CO₂更高的溶解能力和选择性。从加标的砂样中萃取磺胺二甲嘧啶和磺胺二甲氧嘧啶时，使用纯CHF₃的萃取效率比纯CO₂高45%以上；从强化牛肝样品中萃取时，使用纯CHF₃的萃取效率比纯CO₂高200%以上。