Pareja J A, Caminero A B, Millán I
Unidad de Neurología, Hospital Nuestra Señora de Sonsoles, Avila.
Neurologia. 1996 Aug-Sep;11(7):244-7.
Hypersomnia in obstructive sleep apnea syndrome (OSAS) is due to sleep fragmentation caused by arousals related to repeated episodes of apnea. Arousals may also be triggered by other non-apneic respiratory events (NAREs). The contribution of NARE to sleep disruption and nocturnal desaturation has been assessed by evaluating the polysomnograms of 58 consecutive OSAS patients. We studied 28 cases (25 men) presenting more than 5 NAREs/hour of sleep in addition to apneic events. Mean age was 48.8 +/- 14 years, mean body mass index was 38.1 +/- 10.2 kg/m2 and mean oxygen saturation at baseline, before the polysomnogram, was 94.0 +/- 2.5%. The following NARE categories were identified: incomplete apnea, paradoxical breathing, periodic breathing, hypoventilation and snore-arousals. All respiratory arousals were tabulated as indexes (number/hours of sleep). Although the number of apneic arousals was significantly greater, the NARE arousal index, both in REM and non-REM sleep reached the sleep disruption range (around 20 arousals/hour). Apneic desaturations were greater than non-apneic ones, during both REM and non-REM sleep. We conclude that NARE significantly contribute to sleep fragmentation in nearly half the patients with OSAS.
阻塞性睡眠呼吸暂停综合征（OSAS）中的嗜睡是由与反复呼吸暂停发作相关的觉醒引起的睡眠片段化所致。觉醒也可能由其他非呼吸暂停性呼吸事件（NAREs）触发。通过评估58例连续OSAS患者的多导睡眠图，已对NARE对睡眠中断和夜间低氧饱和度的影响进行了评估。我们研究了28例患者（25名男性），除呼吸暂停事件外，每小时睡眠中出现超过5次NAREs。平均年龄为48.8±14岁，平均体重指数为38.1±10.2kg/m²，在进行多导睡眠图检查之前，基线时的平均血氧饱和度为94.0±2.5%。确定了以下NARE类别：不完全呼吸暂停、矛盾呼吸、周期性呼吸、通气不足和鼾声觉醒。所有呼吸觉醒均以指数形式列出（每小时睡眠次数）。尽管呼吸暂停性觉醒的次数明显更多，但REM睡眠和非REM睡眠中的NARE觉醒指数均达到睡眠中断范围（约每小时20次觉醒）。在REM睡眠和非REM睡眠期间，呼吸暂停性低氧饱和度均高于非呼吸暂停性低氧饱和度。我们得出结论，在近一半的OSAS患者中，NARE对睡眠片段化有显著影响。
