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[肌肉注射和口服给药时犬和猴血液中恶喹酸转运的特征]

[The characteristics of oxolinic acid transport in the blood of dogs and monkeys when administered intramuscularly and perorally].

作者信息

Tarkil N Z, Iartsev E I, Novosel'tseva S D, Barkaia V S, Nazarov S M, Znamenskiĭ V V

出版信息

Eksp Klin Farmakol. 1996 May-Jun;59(3):53-6.

PMID:8974586
Abstract

A possibility of testing oxolynic acid (OA) transport in blood of animals by its bactericidal effect was studied experimentally on macaques and non-pedigree dogs (intramuscular and peroral administration). Kinetics of accumulation and elimination of OA and its derivatives exhibiting bactericidal effect makes it possible to predict optimum scheme of using these drugs in prevention and treatment of radiation disease.

摘要

通过其杀菌作用来检测动物血液中奥索利酸(OA)转运的可能性,已在猕猴和非纯种犬身上进行了实验研究(肌肉注射和口服给药)。具有杀菌作用的OA及其衍生物的积累和消除动力学,使得预测这些药物在预防和治疗放射病中的最佳使用方案成为可能。

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