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[神经可塑性]

[Neuronal plasticity].

作者信息

Pascual-Castroviejo I

机构信息

Servicio de Neurología Pediátrica, Hospital La Paz, Madrid.

出版信息

Rev Neurol. 1996 Nov;24(135):1361-6.

PMID:8974738
Abstract

The term 'brain plasticity' means the brain capacity to diminish the effects of the lesions through structural functional changes. A great part of the pathological processes of the nervous system affecting the corticospinal and the subcorticospinal tracts, the cerebellar, spinal, visual, language and other systems show neuronal plasticity, spontaneously in some cases and after suitable rehabilitation in others. The clinical manifestations of neuronal plasticity are observed especially after prenatal, neonatal or childhood cerebral damage. During the adulthood, the brain has less capacity of neuronal plasticity, although plastic changes may be found at any age. Apart the clinic, the neuronal plasticity can be studied through electrophysiology, MR, positron emission tomography (PET), transcranial magnetic stimulation (TME), and obviously by histology, this latter especially in experimental studies. In pediatric Neurology, the concept of brain plasticity is frequently used to explain the favourable clinic evolution in a lot of cases with severe brain injury.

摘要

“脑可塑性”一词是指大脑通过结构功能变化减轻损伤影响的能力。影响皮质脊髓束和皮质下脊髓束、小脑、脊髓、视觉、语言及其他系统的大部分神经系统病理过程都显示出神经元可塑性,有些情况是自发出现,有些情况则是在适当康复后出现。神经元可塑性的临床表现尤其在产前、新生儿期或儿童期脑损伤后可见。在成年期,大脑的神经元可塑性能力较低,尽管在任何年龄都可能发现可塑性变化。除了临床观察外,神经元可塑性还可以通过电生理学、磁共振成像(MR)、正电子发射断层扫描(PET)、经颅磁刺激(TME)进行研究,当然也可以通过组织学研究,后者尤其在实验研究中应用。在儿童神经病学中,脑可塑性的概念经常被用来解释许多严重脑损伤病例中良好的临床演变情况。

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