Ramsay T G
Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, USA.
Endocrinol Metab Clin North Am. 1996 Dec;25(4):847-70. doi: 10.1016/s0889-8529(05)70358-3.
The adipocyte is a metabolically active cell that functions to store energy for times of energy deprivation or enhanced need. Obesity is characterized by increased lipid accumulation and turnover compared with the nonobese state. Both triglyceride synthesis and lipolysis are regulated metabolic processes in the adipocyte. Current research on the metabolic activities of the human adipocyte focus on plasma triglyceride hydrolysis and uptake of fatty acids by LPL, esterification of these fatty acids, and the subsequent triglyceride breakdown by hormone-sensitive lipase in response to stimulation of adrenergic receptors. These topics are discussed in relationship to the development of obesity.
脂肪细胞是一种代谢活跃的细胞,其功能是在能量缺乏或需求增加时储存能量。与非肥胖状态相比,肥胖的特征是脂质积累和周转增加。甘油三酯合成和脂肪分解都是脂肪细胞中受调节的代谢过程。目前关于人类脂肪细胞代谢活动的研究集中在血浆甘油三酯水解、脂蛋白脂肪酶对脂肪酸的摄取、这些脂肪酸的酯化以及随后激素敏感性脂肪酶在肾上腺素能受体刺激下对甘油三酯的分解。这些主题将结合肥胖的发展进行讨论。