1969 - 1993年甲状腺癌的组织学趋势：甲状腺未分化癌相对比例的临床病理分析
Histologic trends in thyroid cancer 1969-1993: a clinico-pathologic analysis of the relative proportion of anaplastic carcinoma of the thyroid.
作者信息
Agrawal S, Rao R S, Parikh D M, Parikh H K, Borges A M, Sampat M B
机构信息
Department of Surgical Oncology, Tata Memorial Hospital, Parel, Bombay, India.
出版信息
J Surg Oncol. 1996 Dec;63(4):251-5. doi: 10.1002/(SICI)1096-9098(199612)63:4<251::AID-JSO7>3.0.CO;2-B.
BACKGROUND
It was observed that new presentations of anaplastic carcinoma of the thyroid had become infrequent in the last two decades.
METHODS
All cases of thyroid cancer seen at our centre between 1969-1993 (n = 2921) were classified as papillary 49%, follicular 34%, medullary 7.5%, anaplastic 4.7%, and other 4.8%. The total number of thyroid cancers show a 3.5-fold rise.
RESULTS
The differentiated thyroid cancers show a significant rising trend as against the relative proportion of anaplastic carcinoma, which shows a significant decline (P = 0.002). Clinicopathologic data on 124 patients of anaplastic carcinoma revealed 50% patients had either long-standing goitres, previous thyroid abnormalities, or associated differentiated thyroid carcinoma on histology.
CONCLUSIONS
The decline in the relative proportion of anaplastic carcinoma may in part be explained by the clinicopathologic findings or it may be attributed to histological reclassification.
背景
据观察，在过去二十年中，甲状腺间变性癌的新发病例已变得不常见。
方法
对1969年至1993年间在我们中心就诊的所有甲状腺癌病例（n = 2921）进行分类，其中乳头状癌占49%，滤泡状癌占34%，髓样癌占7.5%，间变性癌占4.7%，其他类型占4.8%。甲状腺癌的总数显示出3.5倍的增长。
结果
与间变性癌的相对比例相比，分化型甲状腺癌呈现出显著的上升趋势，而间变性癌的比例则显著下降（P = 0.002）。124例间变性癌患者的临床病理数据显示，50%的患者有长期存在的甲状腺肿、既往甲状腺异常或组织学上伴有分化型甲状腺癌。
结论
间变性癌相对比例的下降部分可能由临床病理结果解释，也可能归因于组织学重新分类。
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