Hickey M, Fraser I, Dwarte D, Graham S
Department of Obstetrics and Gynaecology, University of Sydney, NSW, Australia.
Hum Reprod. 1996 Oct;11 Suppl 2:35-44. doi: 10.1093/humrep/11.suppl_2.35.
Long-acting progestogenic contraceptives are frequently associated with disturbances of menstrual bleeding patterns. In particular, irregular, frequent and prolonged bleeding are commonly seen. The mechanism of this irregular bleeding is unknown, but changes in the endometrial vasculature are thought to be of importance. In endometrial biopsies from Norplant users, an increase in endometrial microvascular density has been observed after 3-12 months. Morphological changes in endometrial capillaries following progestogen exposure have suggested an increase in vascular fragility. Little is known about the structure and function of the endometrial vasculature in vivo following exposure to exogenous contraceptive steroids. This study has developed techniques for the assessment of vascular fragility by imposing a mechanical stress on the endometrium and observing subsequent bleeding under direct vision. The techniques were used in a preliminary examination between 1 and 9 months after Norplant insertion, and the study identified a number of morphological and functional characteristics of Norplant-exposed endometrium.
长效孕激素避孕药常常与月经出血模式紊乱有关。特别是不规则、频繁和长期出血较为常见。这种不规则出血的机制尚不清楚，但子宫内膜血管系统的变化被认为很重要。在使用诺普兰（Norplant）的女性的子宫内膜活检中，3至12个月后观察到子宫内膜微血管密度增加。孕激素暴露后子宫内膜毛细血管的形态变化表明血管脆性增加。关于暴露于外源性避孕类固醇后体内子宫内膜血管系统的结构和功能知之甚少。本研究开发了通过对子宫内膜施加机械应力并在直视下观察随后的出血情况来评估血管脆性的技术。这些技术用于诺普兰植入后1至9个月的初步检查，该研究确定了诺普兰暴露子宫内膜的一些形态和功能特征。
