Mayaux M J, Dussaix E, Isopet J, Rekacewicz C, Mandelbrot L, Ciraru-Vigneron N, Allemon M C, Chambrin V, Katlama C, Delfraissy J F, Puel J
SEROGEST Cohort and Unité 292 INSERM, Hôpital Kremlin Bicêtre, France.
J Infect Dis. 1997 Jan;175(1):172-5. doi: 10.1093/infdis/175.1.172.
Virus load in pregnancy and its relation to mother-to-child human immunodeficiency virus (HIV) transmission were studied prospectively. From 1989 to 1994, 320 HIV-infected women from 18 centers had plasma samples stored. Among women not receiving antiretroviral therapy, the polymerase chain reaction RNA level was 3.6 log at delivery, and 15% of women had levels below the detection limit. There was no variation during pregnancy. Women born in sub-Saharan Africa had lower RNA levels, although their CD4 cell distribution did not differ from that in other women. Among 236 evaluable children, 19% +/- 5% were infected. Transmission occurred in 12% of cases (confidence interval, 5%-22%) with <1000 copies/mL versus 29% +/- 10% of those with >10,000 copies/mL (P < .02). Maternal virus load appears strongly related to HIV transmission to the child.
对孕期病毒载量及其与母婴人类免疫缺陷病毒（HIV）传播的关系进行了前瞻性研究。1989年至1994年，来自18个中心的320名感染HIV的女性储存了血浆样本。在未接受抗逆转录病毒治疗的女性中，分娩时聚合酶链反应RNA水平为3.6对数，15%的女性水平低于检测限。孕期无变化。撒哈拉以南非洲出生的女性RNA水平较低，尽管她们的CD4细胞分布与其他女性无异。在236名可评估的儿童中，19%±5%被感染。病毒载量<1000拷贝/毫升的病例中，12%发生传播（置信区间，5%-22%），而病毒载量>10000拷贝/毫升的病例中，29%±10%发生传播（P<.02）。母亲的病毒载量似乎与HIV传播给孩子密切相关。
