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1
Similar DNA recognition properties of alternatively spliced Drosophila POU factors.果蝇可变剪接的POU因子具有相似的DNA识别特性。
Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15097-101. doi: 10.1073/pnas.93.26.15097.
2
POU domain factors of the Brn-3 class recognize functional DNA elements which are distinctive, symmetrical, and highly conserved in evolution.Brn-3类的POU结构域因子识别在进化中独特、对称且高度保守的功能性DNA元件。
Mol Cell Biol. 1997 May;17(5):2391-400. doi: 10.1128/MCB.17.5.2391.
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POU domain factors in neural development.神经发育中的POU结构域因子。
Adv Exp Med Biol. 1998;449:39-53. doi: 10.1007/978-1-4615-4871-3_4.
4
Structure of Pit-1 POU domain bound to DNA as a dimer: unexpected arrangement and flexibility.作为二聚体与DNA结合的Pit-1 POU结构域的结构：意外的排列和灵活性。
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The Oct-1 POU-specific domain can stimulate small nuclear RNA gene transcription by stabilizing the basal transcription complex SNAPc.Oct-1的POU特异性结构域可通过稳定基础转录复合物SNAPc来刺激小核RNA基因转录。
Mol Cell Biol. 1996 May;16(5):1955-65. doi: 10.1128/MCB.16.5.1955.
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POU-specific domain of Oct-2 factor confers 'octamer' motif DNA binding specificity on heterologous Antennapedia homeodomain.Oct-2因子的POU特异性结构域赋予异源触角足同源结构域“八聚体”基序DNA结合特异性。
FEBS Lett. 1992 Dec 21;314(3):361-5. doi: 10.1016/0014-5793(92)81506-h.
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Highly cooperative homodimerization is a conserved property of neural POU proteins.高度协同的同二聚化是神经POU蛋白的保守特性。
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Oct-1 POU domain-DNA interactions: cooperative binding of isolated subdomains and effects of covalent linkage.八聚体转录因子1（Oct-1）的POU结构域与DNA的相互作用：分离的亚结构域的协同结合及共价连接的影响
Genes Dev. 1996 Jan 1;10(1):27-36. doi: 10.1101/gad.10.1.27.
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Solution structure of the Oct-1 POU homeodomain determined by NMR and restrained molecular dynamics.通过核磁共振和受限分子动力学确定的Oct-1 POU同源结构域的溶液结构
J Biomol NMR. 1995 Jul;6(1):23-32. doi: 10.1007/BF00417488.

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Combinatorial activation and repression by seven transcription factors specify Drosophila odorant receptor expression.七种转录因子的组合激活和抑制作用决定了果蝇气味受体的表达。
PLoS Biol. 2012;10(3):e1001280. doi: 10.1371/journal.pbio.1001280. Epub 2012 Mar 13.
2
Abnormal chemosensory jump 6 is a positive transcriptional regulator of the cholinergic gene locus in Drosophila olfactory neurons.异常化学感应跳跃6是果蝇嗅觉神经元中胆碱能基因位点的正向转录调节因子。
J Neurosci. 2002 Jul 1;22(13):5291-9. doi: 10.1523/JNEUROSCI.22-13-05291.2002.
3
Essential role of POU-domain factor Brn-3c in auditory and vestibular hair cell development.POU 结构域因子 Brn-3c 在听觉和前庭毛细胞发育中的重要作用。
Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9445-50. doi: 10.1073/pnas.94.17.9445.
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A novel genetic system to isolate a dominant negative effector on DNA-binding activity of Oct-2.一种用于分离对Oct-2 DNA结合活性起显性负效应作用因子的新型遗传系统。
Nucleic Acids Res. 1997 May 15;25(10):1984-90. doi: 10.1093/nar/25.10.1984.
5
POU domain factors of the Brn-3 class recognize functional DNA elements which are distinctive, symmetrical, and highly conserved in evolution.Brn-3类的POU结构域因子识别在进化中独特、对称且高度保守的功能性DNA元件。
Mol Cell Biol. 1997 May;17(5):2391-400. doi: 10.1128/MCB.17.5.2391.

本文引用的文献

1
Expression domains of the Cf1a POU domain protein during Drosophila development.果蝇发育过程中Cf1a POU结构域蛋白的表达区域。
Rouxs Arch Dev Biol. 1995 Aug;204(7-8):502-508. doi: 10.1007/BF00360858.
2
Brn-3.0 expression identifies early post-mitotic CNS neurons and sensory neural precursors.Brn-3.0表达可识别有丝分裂后早期的中枢神经系统神经元和感觉神经前体细胞。
Mech Dev. 1995 Nov;53(3):291-304. doi: 10.1016/0925-4773(95)00435-1.
3
Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development.转录因子Brn-3.1和Brn-3.2在听觉和视觉系统发育中的作用。
Nature. 1996 Jun 13;381(6583):603-6. doi: 10.1038/381603a0.
4
POU domain factor Brn-3b is required for the development of a large set of retinal ganglion cells.大量视网膜神经节细胞的发育需要POU结构域因子Brn-3b。
Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):3920-5. doi: 10.1073/pnas.93.9.3920.
5
Development and survival of the endocrine hypothalamus and posterior pituitary gland requires the neuronal POU domain factor Brn-2.内分泌下丘脑和垂体后叶的发育与存活需要神经元POU结构域因子Brn-2。
Genes Dev. 1995 Dec 15;9(24):3122-35. doi: 10.1101/gad.9.24.3122.
6
The POU domain transcription factor Brn-2 is required for the determination of specific neuronal lineages in the hypothalamus of the mouse.POU结构域转录因子Brn-2是确定小鼠下丘脑特定神经元谱系所必需的。
Genes Dev. 1995 Dec 15;9(24):3109-21. doi: 10.1101/gad.9.24.3109.
7
Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity.Mad：一种与Max形成异二聚体的伙伴，可拮抗Myc转录活性。
Cell. 1993 Jan 29;72(2):211-22. doi: 10.1016/0092-8674(93)90661-9.
8
Tissue-specific RNA splicing generates an ankyrin-like domain that affects the dimerization and DNA-binding properties of a bHLH protein.组织特异性RNA剪接产生一个锚蛋白样结构域，该结构域影响bHLH蛋白的二聚化和DNA结合特性。
Genes Dev. 1993 Jan;7(1):55-71. doi: 10.1101/gad.7.1.55.
9
Brn-3.0: a POU-domain protein expressed in the sensory, immune, and endocrine systems that functions on elements distinct from known octamer motifs.Brn-3.0：一种在感觉、免疫和内分泌系统中表达的POU结构域蛋白，其作用于与已知八聚体基序不同的元件。
Proc Natl Acad Sci U S A. 1993 Nov 15;90(22):10841-5. doi: 10.1073/pnas.90.22.10841.
10
Crystal structure of the Oct-1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules.与八聚体位点结合的Oct-1 POU结构域的晶体结构：通过连接的DNA结合模块进行DNA识别。
Cell. 1994 Apr 8;77(1):21-32. doi: 10.1016/0092-8674(94)90231-3.

果蝇可变剪接的POU因子具有相似的DNA识别特性。

Similar DNA recognition properties of alternatively spliced Drosophila POU factors.

作者信息

Turner E E

机构信息

Department of Psychiatry, University of California at San Diego, La Jolla 92093-0603, USA.

出版信息

Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15097-101. doi: 10.1073/pnas.93.26.15097.

DOI:10.1073/pnas.93.26.15097
PMID:8986770
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC26362/
Abstract

The POU-IV or "Brn-3" class of POU-domain transcription factors is represented in Drosophila by I-POU and twin-of-I-POU, alternative splice products of the I-POU gene. I-POU has been previously reported to inhibit DNA binding by the POU-III class factor drifter/Cf1a via the formation of heterodimeric complexes. Here we report that expression of the I-POU/tI-POU message is maximal late in the embryonic phase of Drosophila development, and I-POU is the preferred splice variant. Although I-POU lacks two basic amino acid residues in the POU-homeodomain found in tI-POU and Brn-3.0, these three POU-IV class proteins exhibit very similar DNA-binding specificity. In contrast to previously published reports, the results presented here show no effect of I-POU on DNA binding by drifter, and no evidence for I-POU/drifter dimerization. These results suggest that the I-POU/tI-POU gene products function by transcriptional mechanisms similar to those of the homologous POU-IV class factors expressed in other species, not by unique inhibitory mechanism.

摘要

POU-IV 或 “Brn-3” 类 POU 结构域转录因子在果蝇中由 I-POU 和 I-POU 的孪生基因（I-POU 基因的可变剪接产物）代表。先前有报道称，I-POU 通过形成异源二聚体复合物来抑制 POU-III 类因子漂移蛋白/Cf1a 与 DNA 的结合。在此我们报道，I-POU/tI-POU 信息的表达在果蝇发育的胚胎期晚期达到最大值，且 I-POU 是首选的剪接变体。尽管 I-POU 在 tI-POU 和 Brn-3.0 中发现的 POU 同源结构域中缺少两个碱性氨基酸残基，但这三种 POU-IV 类蛋白表现出非常相似的 DNA 结合特异性。与先前发表的报告相反，此处呈现的结果表明 I-POU 对漂移蛋白与 DNA 的结合没有影响，也没有 I-POU/漂移蛋白二聚化的证据。这些结果表明，I-POU/tI-POU 基因产物通过与其他物种中表达的同源 POU-IV 类因子相似的转录机制发挥作用，而非通过独特的抑制机制。