自身免疫性疾病中Th1/Th2平衡的调控

Manipulation of the Th1/Th2 balance in autoimmune disease.

作者信息

Nicholson L B, Kuchroo V K

机构信息

Center For Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA.

出版信息

Curr Opin Immunol. 1996 Dec;8(6):837-42. doi: 10.1016/s0952-7915(96)80013-6.

DOI:10.1016/s0952-7915(96)80013-6

PMID:8994864

Abstract

Many autoimmune diseases are caused by autopathogenic Th1 cells. Because in vitro Th1 and Th2 cells cross-regulate each other, it is likely that the induction of self-antigen-specific Th2 cells can prevent autoimmune disease. In the past year, investigators have further defined the role of Th1 and Th2 cytokines in the induction and regulation of autoimmunity. Furthermore, the role of MHC-antigen-T-cell avidity (strength of signal) in inducing such protective immune responses has been elucidated.

摘要

许多自身免疫性疾病是由自身致病性Th1细胞引起的。由于在体外Th1细胞和Th2细胞相互交叉调节，因此诱导自身抗原特异性Th2细胞很可能预防自身免疫性疾病。在过去的一年里，研究人员进一步明确了Th1和Th2细胞因子在自身免疫诱导和调节中的作用。此外，主要组织相容性复合体-抗原-T细胞亲和力（信号强度）在诱导此类保护性免疫反应中的作用也已得到阐明。