血清可溶性白细胞介素-2受体作为毛细胞白血病患者疾病活动的可靠且非侵入性标志物。

Serum soluble IL-2 receptor as a reliable and noninvasive marker of disease activity in patients with hairy cell leukemia.

作者信息

Chrobák L, Podzimek K, Plísková L, Kerekes Z, Zák P, Voglová J, Spacek J, Palicka V

机构信息

Department of Clinical Hematology, University Hospital, Charles University, Faculty of Medicine, Hradec Králové, Czech Republic.

出版信息

Neoplasma. 1996;43(5):321-5.

PMID:8996552

Abstract

Hairy cell leukemia is a chronic lymphoproliferative disorder of B-cell lineage. Malignant cells express the interleukin-2 receptor (IL-2R) which is released in vitro as well as in vivo. The sera of patients with hairy cell leukemia contain elevated levels of this soluble receptor (sIL-2R). Sera of 24 patients with hairy cell leukemia were tested for sIL-2R. In 9 patients treated with 2-chlorodeoxyadenosine an improved clinical status was associated with decreasing serum sIL-2R. The maximal rate of decrease of sIL-2R level was observed within the second and the third week after the therapy initiation. Patients with disease progression had an increase in serum sIL-2R level. Our results suggest that serial measurement of sIL-2R level can be used as a reliable, noninvasive means to assess the disease activity and its response to therapy.

摘要

毛细胞白血病是一种B细胞系的慢性淋巴细胞增殖性疾病。恶性细胞表达白细胞介素-2受体（IL-2R），该受体在体外和体内均可释放。毛细胞白血病患者的血清中这种可溶性受体（sIL-2R）水平升高。对24例毛细胞白血病患者的血清进行了sIL-2R检测。在9例接受2-氯脱氧腺苷治疗的患者中，临床状况的改善与血清sIL-2R水平的降低相关。sIL-2R水平下降的最大速率在治疗开始后的第二周和第三周内观察到。疾病进展的患者血清sIL-2R水平升高。我们的结果表明，连续测量sIL-2R水平可作为评估疾病活动及其对治疗反应的可靠、非侵入性手段。