Ormseth O A, Nicolson M, Pelleymounter M A, Boyer B B
Institute of Arctic Biology, University of Alaska, Fairbanks 99775, USA.
Am J Physiol. 1996 Dec;271(6 Pt 2):R1775-9. doi: 10.1152/ajpregu.1996.271.6.R1775.
The ob gene product leptin is thought to play a physiological role in the fine tuning of a homeostatic mechanism regulating satiety and adiposity. Mouse recombinant leptin was administered to seasonally hyperphagic arctic ground squirrels as a first step in demonstrating the evolutionary conservation of leptin function and the potential involvement of leptin in the seasonal regulation of adiposity in hibernators. Continuous infusion of leptin for 3 wk via miniosmotic pumps resulted in a reduction in food intake and body weight in a manner consistent with its proposed role as a satiety hormone. During the recovery period after leptin administration, squirrels that had received leptin became hyperphagic relative to controls. Percent body fat was estimated at weekly intervals by measuring total body electrical conductivity and decreased after 3 wk of leptin administration. Our observations support the role of leptin as a regulatory hormone involved in the control of satiety, adiposity, and possibly energy expenditure in hibernating mammals.
肥胖基因（ob基因）的产物瘦素被认为在调节饱腹感和肥胖的稳态机制的微调中发挥生理作用。将小鼠重组瘦素给予季节性食欲亢进的北极地松鼠，这是证明瘦素功能的进化保守性以及瘦素可能参与冬眠动物肥胖的季节性调节的第一步。通过微型渗透泵连续输注瘦素3周，导致食物摄入量和体重下降，其方式与其作为饱腹感激素的假定作用一致。在给予瘦素后的恢复期，接受瘦素的松鼠相对于对照组变得食欲亢进。通过测量全身电导率每周估计一次体脂百分比，在给予瘦素3周后体脂百分比下降。我们的观察结果支持瘦素作为一种调节激素的作用，它参与控制冬眠哺乳动物的饱腹感、肥胖，可能还有能量消耗。
