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[胆管不可切除性肿瘤:姑息性手术与非手术治疗]

[Non-resectable neoplasms of the biliary duct: palliative surgery vs non-surgical management].

作者信息

Tocchi A, Costa G, Lepre L, Liotta G, Mazzoni G, Sita A

机构信息

I Istituto di Clinica Chirurgica, Università degli Studi La Sapienza, Roma.

出版信息

G Chir. 1996 Aug-Sep;17(8-9):408-12.

PMID:9004835
Abstract

A retrospective analysis comparing the results of biliary enteric anastomoses and non-operative management in unresectable bile duct carcinomas was carried out. Twenty-four patients underwent surgical drainage (Group A), and 29 were managed with transhepatic or endoscopic stent (Group B). Concomitant medical diseases were more frequent in group B patients (16.6% vs 48.2%, p < 0.03). Group A and group B were comparable in morbidity (29.1% vs 41.3%), mortality (12.5% vs 13.7%) and 1-year survival rate (21% vs 17%). Median survival was 4.2 months in group A and 2.6 in group B. Jaundice relief was achieved in 70.8% of group A patients and in 68.9% of group B. Group B patients experienced more cholangitis (p = 0.001) and required more hospital readmission (p = 0.0015). Quality of life was better in group A patients, however difference did not reach statistical significance. Therefore, low risk patients with unresectable hilar bile duct tumor and yet good life expectancy may benefit from surgical palliation.

摘要

对不可切除胆管癌患者进行了一项回顾性分析,比较了胆肠吻合术和非手术治疗的结果。24例患者接受了手术引流(A组),29例采用经肝或内镜支架治疗(B组)。B组患者合并内科疾病更为常见(16.6%对48.2%,p<0.03)。A组和B组在发病率(29.1%对41.3%)、死亡率(12.5%对13.7%)和1年生存率(21%对17%)方面具有可比性。A组的中位生存期为4.2个月,B组为2.6个月。A组70.8%的患者黄疸得到缓解,B组为68.9%。B组患者胆管炎发生率更高(p = 0.001),需要再次住院的次数更多(p = 0.0015)。A组患者的生活质量更好,但差异未达到统计学意义。因此,对于不可切除的肝门部胆管肿瘤且预期寿命良好的低风险患者,手术姑息治疗可能有益。

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