衰老垂体中催乳素衍生的淀粉样蛋白。

Westermark P, Eriksson L, Engström U, Eneström S, Sletten K

Department of Pathology, Linköping University, Sweden.

Am J Pathol. 1997 Jan;150(1):67-73.

Small amyloid deposits occur commonly in different organs in association with aging. As in other amyloids, the fibrils in the age-associated forms are built up by specific proteins, unique to every histological type. The amyloid proteins that have been identified in localized amyloid of human endocrine organs have all been of polypeptide hormone nature, and these include calcitonin, islet amyloid polypeptide (amylin), and atrial natriuretic factor. In the present study, we add prolactin to the increasing group of known amyloid proteins and show that this hormone constitutes the amyloid fibrils of pituitary glands of aging individuals.

小淀粉样沉积物常见于不同器官，与衰老相关。与其他淀粉样蛋白一样，与年龄相关的淀粉样纤维由特定蛋白质构成，每种组织学类型都有其独特性。在人类内分泌器官局部淀粉样变中已鉴定出的淀粉样蛋白均具有多肽激素性质，包括降钙素、胰岛淀粉样多肽（胰淀素）和心房利钠因子。在本研究中，我们将催乳素加入已知淀粉样蛋白不断增加的类别中，并表明这种激素构成了衰老个体垂体的淀粉样纤维。