疼痛系统以及调节疼痛的通路的神经解剖学。
Neuroanatomy of the pain system and of the pathways that modulate pain.
作者信息
Willis W D, Westlund K N
机构信息
Department of Anatomy & Neurosciences, University of Texas Medical Branch, Galveston 77555-1069, USA.
出版信息
J Clin Neurophysiol. 1997 Jan;14(1):2-31. doi: 10.1097/00004691-199701000-00002.
We review many of the recent findings concerning mechanisms and pathways for pain and its modulation, emphasizing sensitization and the modulation of nociceptors and of dorsal horn nociceptive neurons. We describe the organization of several ascending nociceptive pathways, including the spinothalamic, spinomesencephalic, spinoreticular, spinolimbic, spinocervical, and postsynaptic dorsal column pathways in some detail and discuss nociceptive processing in the thalamus and cerebral cortex. Structures involved in the descending analgesia systems, including the periaqueductal gray, locus ceruleus, and parabrachial area, nucleus raphe magnus, reticular formation, anterior pretectal nucleus, thalamus and cerebral cortex, and several components of the limbic system are described and the pathways and neurotransmitters utilized are mentioned. Finally, we speculate on possible fruitful lines of research that might lead to improvements in therapy for pain.
我们回顾了许多关于疼痛及其调节机制和途径的近期研究发现，重点关注敏化以及伤害感受器和背角伤害性神经元的调节。我们较为详细地描述了几条上行伤害性通路的组织结构，包括脊髓丘脑束、脊髓中脑束、脊髓网状束、脊髓边缘束、脊髓颈束和突触后背柱通路，并讨论了丘脑和大脑皮层中的伤害性信息处理。描述了下行镇痛系统中涉及的结构，包括导水管周围灰质、蓝斑、臂旁区、中缝大核、网状结构、顶盖前核、丘脑和大脑皮层，以及边缘系统的几个组成部分，并提及了所利用的通路和神经递质。最后，我们推测了可能富有成果的研究方向，这些方向可能会带来疼痛治疗方面的改善。
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