Liepert J, Tegenthoff M, Malin J P
Department of Neurology, Ruhr University Bochum, BG-Kliniken Bergmannsheil Bochum, Federal Republic of Germany.
J Neural Transm (Vienna). 1996;103(8-9):917-24. doi: 10.1007/BF01291782.
The present study was performed in order to determine the influence of ipsilateral transcranial magnetic stimulations (TMS) on the silent period evoked by contralateral cortical stimulations. Ipsilateral TMS preceded the contralateral magnetic or electrical cortex stimulation by 0-50 ms. In all subjects, the duration of the silent period was decreased in interstimulus intervals of 20-30 ms when using magnetic ipsi- and contralateral stimuli. No change in the silent period was seen with ipsilateral magnetic and contralateral electrical stimulations. Decreases of motor evoked potential amplitudes were an inconsistent phenomenon. The results indicate that ipsilateral TMS in activate inhibitory cortical interneurons, probably via transcallosal pathways. Different time courses and different degrees of inhibition indicate that motor excitation and inhibition may be mediated by different neuronal circuits.
本研究旨在确定同侧经颅磁刺激（TMS）对由对侧皮质刺激诱发的静息期的影响。同侧TMS在对侧磁或电皮质刺激之前0 - 50毫秒。在所有受试者中，当使用同侧和对侧磁刺激时，在20 - 30毫秒的刺激间隔中静息期持续时间缩短。同侧磁刺激和对侧电刺激时静息期未见变化。运动诱发电位幅度降低是一种不一致的现象。结果表明，同侧TMS可能通过胼胝体通路激活抑制性皮质中间神经元。不同的时间进程和不同程度的抑制表明，运动兴奋和抑制可能由不同的神经回路介导。
