雄激素受体基因突变数据库。
The androgen receptor gene mutations database.
作者信息
Gottlieb B, Trifiro M, Lumbroso R, Pinsky L
机构信息
Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, 3755 Chemin de la Cote-Ste-Catherine, Montreal, Quebec H3T 1E2, Canada.
出版信息
Nucleic Acids Res. 1997 Jan 1;25(1):158-62. doi: 10.1093/nar/25.1.158.
The current version of the androgen receptor (AR) gene mutations database is described. The total number of reported mutations has risen from 212 to 272. We have expanded the database: (i) by adding a large amount of new data on somatic mutations in prostatic cancer tissue; (ii) by defining a new constitutional phenotype, mild androgen insensitivity (MAI); (iii) by placing additional relevant information on an internet site (http://www.mcgill.ca/androgendb/ ). The database has allowed us to examine the contribution of CpG sites to the multiplicity of reports of the same mutation in different families. The database is also available from EMBL (ftp.ebi.ac.uk/pub/databases/androgen) or as a Macintosh Filemaker Pro or Word file (MC33@musica,mcgill.ca)
本文描述了雄激素受体（AR）基因突变数据库的当前版本。已报道的突变总数从212个增加到了272个。我们对该数据库进行了扩充：（i）添加了大量关于前列腺癌组织体细胞突变的新数据；（ii）定义了一种新的体质性表型，即轻度雄激素不敏感（MAI）；（iii）在网站（http://www.mcgill.ca/androgendb/ ）上放置了更多相关信息。该数据库使我们能够研究CpG位点对不同家族中同一突变报告多样性的影响。该数据库也可从EMBL获取（ftp.ebi.ac.uk/pub/databases/androgen），或作为Macintosh Filemaker Pro或Word文件获取（MC33@musica,mcgill.ca）
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