Hepple R T
Department of Medicine, University of California (San Diego), La Jolla 92028-0623, USA.
Can J Appl Physiol. 1997 Feb;22(1):11-22. doi: 10.1139/h97-002.
The surface area of contact between capillaries and muscle fibres has been suggested to be the site of greatest oxygen flux density in the movement of oxygen from the capillaries to the muscle fibres. A new measurement of tissue capillarity, designed specifically for use on non-perfusion fixed muscle tissue (i.e., that obtained via needle biopsy), is presented that describes the capillary supply from this perspective. The Capillary-to-Fibre Perimeter Exchange Index (the CFPE Index) is derived as the quotient of the individual capillary-to-fibre ratio (i.e., the capillary-to-fibre ratio calculated for each fibre individually) and the fibre perimeter. This method is suggested to provide a means of quantitating potential alterations in the capacity for oxygen flux (e.g., as may occur in response to a training intervention) and any carrier- or receptor-mediated aspect of blood-tissue exchange between the capillaries and muscle-fibres (e.g., insulin or glucose delivery).
毛细血管与肌纤维之间的接触表面积被认为是氧气从毛细血管向肌纤维移动过程中氧通量密度最大的部位。本文提出了一种专门用于非灌注固定肌肉组织（即通过针吸活检获得的组织）的组织毛细血管密度新测量方法，该方法从这一角度描述了毛细血管供应情况。毛细血管与纤维周长交换指数（CFPE指数）是通过个体毛细血管与纤维比率（即分别为每根纤维计算的毛细血管与纤维比率）与纤维周长的商得出的。该方法被认为提供了一种量化氧通量能力潜在变化（例如，可能因训练干预而发生的变化）以及毛细血管与肌纤维之间血液 - 组织交换中任何载体或受体介导方面（例如胰岛素或葡萄糖递送）的手段。
