Saiki I
Dept. of Pathogenic Biochemistry, Research Institute for Wakan-yaku, Toyama Medical and Pharmaceutical University.
Gan To Kagaku Ryoho. 1997 Jan;24(2):187-95.
During the metastatic cascade, a tumor cell passes through several connective tissue barriers which consist of various adhesive molecules, such as fibronectin, laminin, collagens, and other glucoproteins and proteoglycans. Tumor invasion is a complex process involving cell adhesion, motility (migration), and the degradation of tissue barriers caused by the different proteases secreted by tumor cells. Therefore, understanding the invasion mechanism and the control mechanisms of the invasive properties of tumor cells may help in the development of anti-metastatic and anti-invasive therapies. We here focused our attention on the functional molecules involved in the invasive process as targets to control tumor metastasis, and screened the inhibitors of tumor invasion into basement membranes.
在转移级联过程中，肿瘤细胞会穿过由多种黏附分子组成的几个结缔组织屏障，这些黏附分子包括纤连蛋白、层粘连蛋白、胶原蛋白以及其他糖蛋白和蛋白聚糖。肿瘤侵袭是一个复杂的过程，涉及细胞黏附、运动性（迁移）以及肿瘤细胞分泌的不同蛋白酶所导致的组织屏障降解。因此，了解肿瘤细胞的侵袭机制和侵袭特性的控制机制可能有助于开发抗转移和抗侵袭疗法。我们在此将注意力集中在侵袭过程中涉及的功能分子上，将其作为控制肿瘤转移的靶点，并筛选了肿瘤侵袭基底膜的抑制剂。
