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[外周血和骨髓造血干细胞自体移植的成本差异。对某中心1年内淋巴瘤、霍奇金病和骨髓瘤移植情况的回顾性分析]

[Difference in costs of autologous transplantation of peripheral and bone marrow hematopoietic stem cells. A retrospective analysis over 1 year of transplantation in lymphoma, Hodgkin's disease and myeloma in a Center].

作者信息

Rio B, Marjanovic Z, Belhocine R, Vekhoff A, Andrieu V, Klaren J, Boccaccio C, Delmer A, Ajchenbaum-Cymbalista F, Hunault M, Bazarbachi A, Lévy V, Andreu G, Zittoun R

机构信息

Service d'Hématologie et Service d'Hémobiologie, Hôtel-Dieu, Paris.

出版信息

Ann Med Interne (Paris). 1996;147(5):313-9.

PMID:9033732
Abstract

The study analysed the financial benefits of transplantation with peripheral blood stem-cells primed after chemotherapy and growth factor in comparison with bone marrow transplantation. Twenty-three consecutive transplantations were performed during one year: 14 peripheral blood stem-cell (CSC group) and 9 bone marrow transplantations (MO group). No differences in patients characteristics were seen between the two groups except for higher number of "BEAM" conditioning in CSC group. Were analyzed delay in neutrophil and platelet recovery, numbers of days in hospital, with fever, under antibiotics, costs of supportive therapy, stem-cell collection and cryopreservation. Difference was significant for duration of neutropenia with advantages in CSC group, but the number on days in hospital, with fever or under antibiotics were similar. Number of platelet transfusions was reduced in CFC group: this economical advantage was lost with the cost of growth factor used for priming stem-cells stem-cell collections and cryopreservations. In our retrospective study, financial advantages associated to peripheral blood stem-cell transplantation was not verified.

摘要

该研究分析了化疗和生长因子预处理后的外周血干细胞移植与骨髓移植相比的经济效益。在一年中连续进行了23例移植:14例外周血干细胞移植(CSC组)和9例骨髓移植(MO组)。除CSC组中“BEAM”预处理次数较多外,两组患者特征未见差异。分析了中性粒细胞和血小板恢复延迟、住院天数、发热天数、使用抗生素天数、支持治疗费用、干细胞采集和冷冻保存费用。中性粒细胞减少持续时间差异有统计学意义,CSC组具有优势,但住院天数、发热天数或使用抗生素天数相似。CSC组血小板输注次数减少:但由于用于预处理干细胞的生长因子成本、干细胞采集和冷冻保存,这种经济优势丧失。在我们的回顾性研究中,未证实外周血干细胞移植具有经济效益。

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