缺血肌肉中的血流以及葡萄糖和氨基酸的摄取

Blood flow and uptake of glucose and amino acids in ischemic muscle.

作者信息

Carroll J E, Kaiser K K, Bondy S C, Purdy J L

出版信息

J Neurol Sci. 1977 Aug;33(1-2):155-60. doi: 10.1016/0022-510x(77)90189-7.

Abstract

In order to examine muscle ischemia, muscle blood flow in the rat hindlimb was decreased by vessel ligation. Amino acid uptake, studied with [14C]alpha-aminoisobutyric acid, was decreased in ischemic Type I (soleus) muscle. Glucose uptake, studied with [14C]deoxyglucose, was increased in Type I muscle. These changes were temporally associated with histologic changes of ischemia in soleus muscle. Denervation, atrophy, and hypertrophy also produced uptake changes with these techniques, and although more prominent in soleus, the changes were also seen in Type II muscle.

摘要

为了研究肌肉缺血，通过血管结扎减少大鼠后肢的肌肉血流量。用[14C]α-氨基异丁酸研究的氨基酸摄取在缺血的I型（比目鱼肌）肌肉中减少。用[14C]脱氧葡萄糖研究的葡萄糖摄取在I型肌肉中增加。这些变化与比目鱼肌缺血的组织学变化在时间上相关。去神经、萎缩和肥大也会通过这些技术产生摄取变化，尽管在比目鱼肌中更明显，但在II型肌肉中也可见到这些变化。