Rapid enlargement of cardiac rhabdomyoma during corticotropin therapy for infantile spasms.
作者信息
Hishitani T, Hoshino K, Ogawa K, Uehara R, Kitazawa R, Hamano S, Nara T, Ogawa Y
机构信息
Department of Cardiology, Saitama Children's Medical Center, Japan.
出版信息
Can J Cardiol. 1997 Jan;13(1):72-4.
OBJECTIVE
To investigate the influence of corticotropin therapy on cardiac rhabdomyoma.
DESIGN
Analysis of data from echocardiography performed on in-patients.
PATIENTS
Six patients with rhabdomyoma who were admitted to the authors' medical centre with either convulsion (five cases) or prematurity (one case) between 1985 and 1995. Five had tuberous sclerosis.
INTERVENTION
Size of cardiac tumours of each patient was measured by echocardiography, and volume index was calculated as the ratio of the tumour volume to its initial volume.
MAIN RESULT
Increase in size of some of the tumours was found during corticotropin therapy on follow-up echocardiography. Maximum volume indexes of tumours in the case of patients (n = 4) who did not receive corticotropin therapy was 1.2 to 3.7, whereas those of patients (n = 2) who received therapy was 9.1 to 12; one of the latter patients died.
CONCLUSION
Corticotropin may contribute to the enlargement of cardiac rhabdomyoma. The size of cardiac rhabdomyomas must be carefully followed when patients are treated with corticotropin.
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